Bernhard Brüne Selected Research

Hyperalgesia

1/2018	The prostaglandin E2 receptor EP3 controls CC-chemokine ligand 2-mediated neuropathic pain induced by mechanical nerve damage.
1/2018	The G2A Receptor Controls Polarization of Macrophage by Determining Their Localization Within the Inflamed Tissue.
6/2014	Hypoxia-inducible factor 1 regulates heat and cold pain sensitivity and persistence.
12/2012	Inhibition of GTP cyclohydrolase reduces cancer pain in mice and enhances analgesic effects of morphine.

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Bernhard Brüne Research Topics

Disease

92	Neoplasms (Cancer) 02/2024 - 01/2002
72	Hypoxia (Hypoxemia) 02/2024 - 01/2003
51	Inflammation (Inflammations) 11/2023 - 07/2006
17	Breast Neoplasms (Breast Cancer) 12/2022 - 10/2012
14	Sepsis (Septicemia) 10/2020 - 04/2005
13	Neoplasm Metastasis (Metastasis) 01/2022 - 06/2013
9	Atherosclerosis 04/2024 - 06/2003
7	Psoriasis (Pustulosis Palmaris et Plantaris) 01/2022 - 01/2017
5	Colonic Neoplasms (Colon Cancer) 01/2024 - 07/2006
5	Hepatocellular Carcinoma (Hepatoma) 01/2022 - 09/2004
5	Renal Cell Carcinoma (Grawitz Tumor) 05/2021 - 04/2004
5	Necrosis 10/2013 - 03/2005
4	Colorectal Neoplasms (Colorectal Cancer) 01/2024 - 05/2011
4	Peritonitis 11/2023 - 01/2020
4	Lung Neoplasms (Lung Cancer) 10/2022 - 03/2009
4	Carcinoma (Carcinomatosis) 01/2022 - 07/2006
4	Hyperalgesia 01/2018 - 12/2012
4	Neuralgia (Stump Neuralgia) 01/2018 - 03/2014
3	Fibrosarcoma 02/2024 - 05/2016
3	Infections 01/2023 - 01/2019
3	Asthma (Bronchial Asthma) 01/2022 - 01/2009
3	Pain (Aches) 01/2018 - 03/2014
3	Obesity 11/2016 - 01/2016
3	Insulin Resistance 11/2016 - 05/2014
2	Adenocarcinoma 10/2023 - 10/2009
2	COVID-19 01/2023 - 01/2023

Drug/Important Bio-Agent (IBA)

36	Proteins (Proteins, Gene)FDA Link 02/2024 - 05/2003
22	Messenger RNA (mRNA)IBA 02/2024 - 04/2004
21	Transcription Factors (Transcription Factor)IBA 12/2017 - 02/2003
20	CytokinesIBA 01/2021 - 07/2006
19	Oxygen (Dioxygen)IBA 12/2022 - 01/2003
17	IronIBA 02/2024 - 05/2005
16	LipidsIBA 11/2023 - 03/2009
14	EnzymesIBA 04/2024 - 07/2006
13	Lipocalin-2IBA 05/2021 - 12/2011
12	Hypoxia-Inducible Factor 1IBA 09/2014 - 04/2004
11	Dinoprostone (PGE2)FDA Link 11/2023 - 12/2012
11	sphingosine 1-phosphate (sphingosine-1-phosphate)IBA 01/2022 - 10/2007
10	MicroRNAs (MicroRNA)IBA 04/2022 - 01/2012
10	Nitric Oxide (Nitrogen Monoxide)FDA Link 01/2019 - 05/2003
9	ProstaglandinsIBA 01/2023 - 01/2011
8	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2021 - 10/2005
7	Conditioned Culture MediaIBA 01/2020 - 10/2007
6	RNA (Ribonucleic Acid)IBA 10/2023 - 01/2019
6	oxidized low density lipoproteinIBA 01/2021 - 05/2003
6	Sphingosine-1-Phosphate ReceptorsIBA 01/2019 - 01/2009
6	Fatty Acids (Saturated Fatty Acids)IBA 01/2019 - 06/2011
6	PPAR gammaIBA 06/2015 - 01/2006
5	CholesterolIBA 04/2024 - 01/2021
5	ZymosanIBA 02/2021 - 01/2018
5	Interleukin-17 (Interleukin 17)IBA 01/2021 - 06/2018
5	Imiquimod (Aldara)FDA LinkGeneric 01/2020 - 01/2017
5	Peroxisome Proliferator-Activated Receptors (PPAR)IBA 01/2020 - 07/2011
5	sphingosine kinaseIBA 01/2019 - 01/2009
5	Superoxides (Superoxide)IBA 10/2018 - 03/2005
4	SphingolipidsIBA 01/2024 - 01/2019
4	LipopolysaccharidesIBA 01/2023 - 09/2010
4	Prostaglandin-E SynthasesIBA 01/2022 - 01/2011
4	TristetraprolinIBA 01/2021 - 09/2010
4	thiamine triphosphorate (TTP)IBA 01/2021 - 09/2010
4	Interleukin-1 (Interleukin 1)IBA 01/2021 - 10/2016
4	Glucose (Dextrose)FDA LinkGeneric 01/2021 - 04/2010
4	InterleukinsIBA 07/2020 - 01/2013
4	Phosphotransferases (Kinase)IBA 01/2019 - 04/2004
4	LigandsIBA 01/2018 - 06/2015
4	Interleukin-6 (Interleukin 6)IBA 10/2017 - 09/2010
4	Interleukin-10 (Interleukin 10)IBA 01/2015 - 11/2009
4	Prostaglandins EIBA 10/2013 - 01/2011
4	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 09/2010 - 06/2003
4	Prolyl Hydroxylases (Prolyl Hydroxylase)IBA 09/2008 - 05/2005
3	dihydroceramide desaturaseIBA 01/2024 - 01/2017
3	AntigensIBA 11/2023 - 01/2009
3	ChemokinesIBA 01/2023 - 02/2011
3	Cytochrome P-450 Enzyme System (Cytochrome P450)IBA 07/2021 - 01/2019
3	Lipoproteins (Lipoprotein)IBA 01/2021 - 05/2003
3	Chelating AgentsIBA 02/2020 - 05/2005
3	Toll-Like Receptors (Toll-Like Receptor)IBA 01/2020 - 06/2018
3	Arachidonic Acid (Vitamin F)IBA 01/2020 - 01/2006
3	Neutralizing AntibodiesIBA 01/2020 - 01/2016
3	EicosanoidsIBA 01/2020 - 12/2012
3	p38 Mitogen-Activated Protein KinasesIBA 01/2020 - 07/2006
3	Interleukin-27 (Interleukin 27)IBA 01/2020 - 06/2012
3	Histones (Histone)IBA 01/2019 - 02/2011
3	Oxaliplatin (Eloxatin)FDA LinkGeneric 10/2018 - 05/2011
3	Interleukin-12 (IL 12)IBA 03/2018 - 11/2009
3	PalmitatesIBA 01/2016 - 05/2014
3	Hormones (Hormone)IBA 09/2014 - 07/2006
3	PolyphenolsIBA 07/2014 - 07/2006
3	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 03/2012 - 09/2009
3	NF-kappa B (NF-kB)IBA 10/2007 - 06/2003
2	LeukotrienesIBA 01/2023 - 01/2018
2	Toll-Like Receptor 4IBA 01/2023 - 01/2014
2	InterferonsIBA 01/2023 - 06/2018
2	Ferritins (Ferritin)IBA 01/2023 - 01/2020

Therapy/Procedure

34	Therapeutics 12/2023 - 04/2005
6	Drug Therapy (Chemotherapy) 12/2022 - 10/2018
5	Ligation 01/2019 - 07/2011
5	Punctures 01/2019 - 07/2011
4	Immunotherapy 10/2023 - 01/2009
2	Aftercare (After-Treatment) 01/2023 - 02/2011